Mighty Self CBD Capsules
To shop Mighty Self CBD Capsules, visit their shop here.
When a colleague introduced us to Mighty Self, we were intrigued. At Hempsley, we are all about teaching you how to support your endocannabinoid system, both with and without cannabis — so when we saw that this product combined other healing herbs with cannabis, we knew that we wanted to learn more about it.
Quick Facts about Mighty Self CBD:
Mighty Self CBD was founded in 2016 and sold its first product in 2019
Mighty Self CBD is owned by Mighty Self, whose two primary owners are Matthew Runeare and Dave Rothenberg
Mighty Self CBD’s hemp is sun grown in Kentucky and extracted with CO2 for a full-spectrum product with trace amounts of THC totaling less than 0.3%
How to use Mighty Self CBD Capsules
It’s important to remember that every person’s minimum effective dose, or M.E.D., is unique to their body and metabolism. To find your M.E.D, Mighty Self CBD recommends starting with one capsule and waiting at least one hour to determine if it delivers the desired result. If one capsule turns out to not be your M.E.D. (meaning you don’t get the desired result — whether it’s an increase in focus, reduced anxiety, etc), increase dosage one capsule at a time with a maximum of 4 capsules per 24 hour period.
Take note of how you’re feeling throughout the day, recording in a journal if possible. Once you find your “sweet spot,” use that dose moving forward, making sure to pay attention to how your needs may change over time (some people report being able to lower their dose while others report needing to increase — remember, everyone is different!). And remember, since you’re ingesting this capsule, it could take anywhere from 30-120 minutes to take effect.
What reviewers had to say
Mighty Self is nutraceutical designed to help you find your Minimum Effective Dose or M.E.D
Every medicine has a minimum effective dose and a maximum tolerated dose. Somewhere in between there is typically what is prescribed as an “effective dose” for a patient.
While it’s generally considered safe to ingest even large amounts of CBD at a time (see our CBD Safety article here for more information), that doesn’t necessarily mean that you should. Because CBD slows the breakdown of our own endocannabinoids so that our bodies can use more of what they’re naturally producing, there comes a point where that breakdown can’t be slowed any further, and the extra CBD will simply be excreted through your urine like any other supplement.
This is why a minimum effective dose, or the smallest dose that produces the effects you’re looking for, is good to look for when using CBD. Not only does this help with the cost of using CBD over time, but it also ensures that your body isn’t doing any extra, unnecessary work.
The typical dose of CBD has been increasing over time and is currently around 30mg, but if you’re someone who’s trying to use CBD just to help with maintaining an overall balanced state, this simply may be more than you need. Mighty Self’s Balance capsules have just 10mg of CBD, making it easy to start low and increase as needed.
More than just CBD
Like we mentioned, these little capsules have more than just CBD — they’re packed with tons of other bioactive ingredients to help increase the efficacy of everything inside. Let’s take a look at these compounds and their benefits:
195mg Phenethylamine (PEA)*
Promotes a Healthy Mood
Supports Focus & Clarity
PEA is an organic compound found in foods like chocolate, beans, and nuts. It acts in the body as a neurotransmitter and has been studied for its impact on focus, mood, and energy.  Below normal levels of PEA have been linked to mood and attention problems. 
102mg Curcumin + 4mg Piperine*
Promotes Healthy Inflammatory Response
Provides Antioxidant & Cell-Protective Activity
Curcumin is a compound found in Turmeric, which has been used as both a spice and traditional medicine for thousands of years. Curcumin is one of the most extensively investigated products of natural origin with many studies validating its role in promoting a healthy inflammatory response and its antioxidant activity. [15,16] Paired with Piperine to boost the bioavailability of Curcumin.
Promotes Brain Function
Supports Energy Production
The cacao bean contains an antioxidant compound called theobromine, which acts as a stimulant on the nervous system with effects similar to caffeine.  Compounds in cacao have also been studied for their effect on cognitive function in older adults. 
Balances Metal & Physical Energy
Promotes Immune Health
Restores Natural Vitality
Ashwagandha is an Ayurvedic herb that has been used traditionally, and is widely used today, as an adaptogen for restoring physical and mental energy while balancing the effects of daily stress. [9,10] It may also help activate the immune system  and improve cognitive function. 
Promotes Calming & Relaxation
Helps Ease Occasional Simple Nervous Tension
Supports Focus & Attention
L-theanine is an amino acid found almost exclusively in green tea that has been used both traditionally and in modern research for its calming influence. L-theanine has specific and positive effects on the brain and nervous system and is known for promoting relaxation and easing tension without causing drowsiness. 
Promotes Mental Awareness
Supports Sustained Energy
Hordenine is naturally found in many plant foods, particularly barley (AKA Hordeum vulgare) from which it was named. It has been suggested that hordenine may promote energy and focus due to its ability to help nerve cells release adrenaline. [3,4]
40mg DL-Phenylalanine (DLPA)*
Supports Healthy Mood
Helps Restore Alertness When Experiencing Occasional Mental Fatigue
DLPA can help produce compounds like dopamine and adrenaline, which are fundamental for mental alertness and focus, supporting the body when under stressful conditions. DLPA has also been suggested to elevate mood, focus, and mental energy [5-8].
Supports a Healthy Inflammatory Response
Promotes a Feeling of Relaxation
Maintains a Healthy Nervous System
CBD increases the levels of our own naturally occurring endocannabinoid anandamide, which helps regulate serotonin and dopamine — the neurotransmitters that trigger our emotions. 
Because of this, CBD has been widely studied for its potential role in supporting behavioral and emotional issues related to feelings of stress and anxiousness.[18,19]
Studies have also explored the role of CBD for use in positively influencing a healthy inflammatory response, [19-21] and research is suggesting that CBD may have a neuroprotective effect. [22-24]
A personal exploration, now shared
Mighty Self was founded in San Francisco, CA by Matthew Runeare and Dave Rothenberg who were two working professionals and parents exploring new ways to alleviate stress, lift their mood, boost energy, enhance focus — and, overall, just be more productive.
In 2016, Matthew and Dave found that CBD was making a big difference in their day-to-day lives and experimented with many different formulations, incorporating other herbal ingredients like ashwagandha and curcumin. They soon realized that when they blended CBD with these other compounds, the effects seemed to become even more beneficial:
At first, they just used the little capsules personally, then they began sharing with friends and family. The feedback was so positive that they decided to turn Mighty Self into a company so they could share it with even more people — and officially sold their first bottle of capsules in January 2019.
MightySelf is currently doing a crowdfunding campaign through MicroVentures that offers anyone the opportunity to contribute to the company in exchange for shares; if you’re interested, check out the link here.
1. Sabelli H, Fink P, Fawcett J, et al. Sustained antidepressant effect of PEA replacement. J Neuropsychiatry Clin Neurosci. 1996 Spring;8(2):168-71. [PMID: 9081552]
2. Janssen PA, Leysen JE, Megens AA, et al. Does phenylethylamine act as an endogenous amphetamine in some patients? Int J Neuropsychopharmacol. 1999 Sep;2(3):229-240. [PMID: 11281991]
3. Hapke HJ, Strathmann W. [Pharmacological effects of hordenine]. Dtsch Tierarztl Wochenschr. 1995 Jun;102(6):228-32. [PMID: 8582256]
4. O’Donnell J, Zeppenfeld D, McConnell E, et al. Norepinephrine: A Neuromodulator That Boosts the Function of Multiple Cell Types to Optimize CNS Performance. Neurochemical research. 2012;37(11):2496-2512. doi:10.1007/s11064-012-0818-x.
5. Fugh-Berman A, Cott JM. Dietary supplements and natural products as psychotherapeutic agents. Psychosom Med. 1999 Sep-Oct;61(5):712-28. [PMID: 10511018]
6. Sabelli HC, Fawcett J, Gusovsky F, Javaid JI, Wynn P, Edwards J, Jeffriess H, Kravitz H. Clinical studies on the phenylethylamine hypothesis of affective disorder: urine and blood phenylacetic acid and phenylalanine dietary supplements. J Clin Psychiatry. 1986 Feb;47(2):66-70. [PMID: 3944066]
7. Kravitz HM, Sabelli HC, Fawcett J. Dietary supplements of phenylalanine and other amino acid precursors of brain neuroamines in the treatment of depressive disorders. J Am Osteopath Assoc. 1984 Sep;84(1 Suppl):119-23.[PMID: 6490415]
8. Beckmann H, Strauss MA, Ludolph E. Dl-phenylalanine in depressed patients: an open study. J Neural Transm. 1977;41(2-3):123-34. [PMID: 335027]
9. Hill RA, Wallace LJ, Miller DD, et al. Structure--activity studies for alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropanoic acid receptors: acidic hydroxyphenylalanines. J Med Chem. 1997 Sep 26;40(20):3182-91. [PMID: 9379437]
10. Mikolai J, Erlandsen A, Murison KA, et al. In vivo effects of Ashwagandha (Withania somnifera) extract on the activation of lymphocytes. The Journal of Alternative and Complementary Medicine. 2009; 15:423-430. [PMID: 19388865]
11. Wadhwa R, Konar A, Kaul SC. Nootropic potential of Ashwagandha leaves: Beyond traditional root extracts. Neurochem Int. 2016 May;95:109-18. [PMID: 26361721]
12. Martínez-Pinilla E, Oñatibia-Astibia A, Franco R. The relevance of theobromine for the beneficial effects of cocoa consumption. Frontiers in Pharmacology. 2015;6:30. [PMID: 25750625]
13. Mastroiacovo D, Kwik-Uribe C, Grassi D, et al. Cocoa flavanol consumption improves cognitive function, blood pressure control, and metabolic profile in elderly subjects: the Cocoa, Cognition, and Aging (CoCoA) Study—a randomized controlled trial. Am J Clin Nutr. 2015 Mar;101(3):538-48. [PMID: 25733639]
14. Sathyapalan T, Beckett S, Rigby AS, et al. High cocoa polyphenol rich chocolate may reduce the burden of the symptoms in chronic fatigue syndrome. Nutr J. 2010 Nov 22;9:55. [PMID: 21092175]
15. Kunnumakkara AB, Bordoloi D, Padmavathi et al. Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases. Br J Pharmacol. 2017 Jun;174(11):1325-1348. [PMID: 27638428]
16. National Academies of Sciences, Engineering, and Medicine, Health and Medicine Division, Board on Population Health and Public Health Practice, Committee on the Health Effects of Marijuana: An Evidence Review and Research Agenda. The Health Effects of Cannabis and Cannabinoids: The Current State of Evidence and Recommendations for Research. Washington (DC): National Academies Press (US); 2017 Jan 12. [PMID: 28182367]
17. Lutz B, Marsicano G, Maldonado R, et al. The endocannabinoid system in guarding against fear, anxiety and stress. Nat Rev Neurosci. 2015 Dec;16(12):705-18. [PMID: 26585799]
18. Abrams DI. The therapeutic effects of Cannabis and cannabinoids: An update from the National Academies of Sciences, Engineering and Medicine report. Eur J Intern Med. 2018 Mar;49:7-11. [PMID: 29325791]
19. Xiong W, Cui T, Cheng K, et al. Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors. The Journal of Experimental Medicine. 2012;209(6):1121-1134. [PMID: 22585736]
20. Watzl B, Scuderi P, Watson RR. Marijuana components stimulate human peripheral blood mononuclear cell secretion of interferon-gamma and suppress interleukin-1 alpha in vitro. Int J Immunopharmacol. 1991;13(8):1091-7. [PMID: 1667651]
21. Iuvone T, Esposito G, Esposito R, et al. Neuroprotective effect of cannabidiol, a non-psychoactive component from Cannabis sativa, on beta-amyloid-induced toxicity in PC12 cells. J Neurochem. 2004 Apr;89(1):134-41. [PMID: 15030397]
22. Izzo AA, Borrelli F, Capasso R, et al. Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb. Trends Pharmacol Sci. 2009 Oct;30(10):515-27. [PMID: 19729208]
23. Zuardi AW. Cannabidiol: from an inactive cannabinoid to a drug with wide spectrum of action. Rev Bras Psiquiatr. 2008 Sep;30(3):271-80. [PMID: 18833429]
24. Nathan PJ, Lu K, Gray M, et al. The neuropharmacology of L-theanine (N-ethylL-glutamine): a possible neuroprotective and cognitive enhancing agent. J Herb Pharmacother. 2006;6(2):21-30. [PMID: 17182482]
25. Lu K, Gray MA, Oliver C, et al. The acute effects of L-theanine in comparison with alprazolam on anticipatory anxiety in humans. Hum Psychopharmacol Clin Exp 2004;19:457–65. [PMID: 15378679]
*These statements have not been evaluated by the Food and Drug Administration. The efficacy of this product has not been confirmed by FDA-approved research. This product is not intended to diagnose, treat, cure or prevent any disease. All information presented here is not meant as a substitute for or alternative to information from health care practitioners. Please consult your health care professional about potential interactions or other possible complications before using any product. The Federal Food, Drug and Cosmetic Act requires this notice.
**This product contains CBD that has been derived from hemp that has been grown in compliance with the 2018 Farm Bill, and contains between 0-0.3% THC.
This review was sponsored by Mighty Self CBD, and the products shown were gifted to Hempsley in order to conduct this review.
Mighty Self CBD’s sponsorship supported our mission to bring you free, quality education by allowing us to purchase props, create original imagery, perform research, write and edit content, & host events in our local community. Although this is a sponsored review, we assure you that we are committed to bringing you unbiased information and promise that all thoughts and opinions are our own. Thank you for your support!
"Hempsley is a living collection of information about holistic wellness techniques. Our mission is to empower you with knowledge so that you can begin taking better care of yourself + your loved ones."
This review was written by Kristen Williams. Copyright © Hempsley® 2019, All Rights Reserved